SrasV1, Main, Exploration, bibRecord, 001232

Synthesis and antiviral activity of maleopimaric and quinopimaric acids' derivatives.

Identifieur interne : 001232 ( Main/Exploration ); précédent : 001231; suivant : 001233

Synthesis and antiviral activity of maleopimaric and quinopimaric acids' derivatives.

Auteurs : Elena V. Tretyakova [Russie] ; Irina E. Smirnova [Russie] ; Elena V. Salimova [Russie] ; Victor N. Odinokov [Russie]

Source :

Bioorganic & medicinal chemistry [ 1464-3391 ] ; 2015.

RBID : pubmed:26372075

Descripteurs français

KwdFr :
- Antiviraux (), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Relation structure-activité, Structure moléculaire, Tests de sensibilité microbienne, Triterpènes (), Triterpènes (pharmacologie), Triterpènes (synthèse chimique), Virus ().
MESH :
- pharmacologie : Antiviraux, Triterpènes.
- synthèse chimique : Antiviraux, Triterpènes.
- Antiviraux, Relation structure-activité, Structure moléculaire, Tests de sensibilité microbienne, Triterpènes, Virus.

English descriptors

KwdEn :
- Abietanes (chemical synthesis), Abietanes (chemistry), Abietanes (pharmacology), Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Microbial Sensitivity Tests, Molecular Structure, Structure-Activity Relationship, Triterpenes (chemical synthesis), Triterpenes (chemistry), Triterpenes (pharmacology), Viruses (drug effects).
MESH :
- chemical , chemical synthesis : Abietanes, Antiviral Agents, Triterpenes.
- chemical , chemistry : Abietanes, Antiviral Agents, Triterpenes.
- chemical , pharmacology : Abietanes, Antiviral Agents, Triterpenes.
- drug effects : Viruses.
- Microbial Sensitivity Tests, Molecular Structure, Structure-Activity Relationship.

Abstract

A series of maleopimaric and quinopimaric acids' derivatives modified in the E-ring, at the carbonyl- and carboxyl-groups were synthesized and evaluated for their activity in vitro against respiratory viruses (influenza; rhinovirus; adenovirus; and SARS), papilloma virus, and hepatitis B and C viruses. The antiviral screening of levopimaric acid diene adducts derivatives was carried out with minimal effect on SARS and influenza type B viruses. Excellent antiviral activity of the ozonolysis product of maleopimaric acid and dihydroquinopimaric methyl-(2-methoxycarbonyl)ethylene amide was found toward papilloma virus (HPV-11 strain) with the selectivity index of SI 30 and 20, respectively. Methyl (2-methoxycarbonyl)ethylene-, 1β-hydroxy-5'-kaprolaktamo- and 4β-hydroxy-4α,14α-epoxy-13(15)-ene-dihydroquinopimaric acid derivatives have also shown activity against replication of HCV nucleic acid and low toxicity.

DOI: 10.1016/j.bmc.2015.09.006
PubMed: 26372075

Affiliations:

Russie

Le document en format XML

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<front><div type="abstract" xml:lang="en">A series of maleopimaric and quinopimaric acids' derivatives modified in the E-ring, at the carbonyl- and carboxyl-groups were synthesized and evaluated for their activity in vitro against respiratory viruses (influenza; rhinovirus; adenovirus; and SARS), papilloma virus, and hepatitis B and C viruses. The antiviral screening of levopimaric acid diene adducts derivatives was carried out with minimal effect on SARS and influenza type B viruses. Excellent antiviral activity of the ozonolysis product of maleopimaric acid and dihydroquinopimaric methyl-(2-methoxycarbonyl)ethylene amide was found toward papilloma virus (HPV-11 strain) with the selectivity index of SI 30 and 20, respectively. Methyl (2-methoxycarbonyl)ethylene-, 1β-hydroxy-5'-kaprolaktamo- and 4β-hydroxy-4α,14α-epoxy-13(15)-ene-dihydroquinopimaric acid derivatives have also shown activity against replication of HCV nucleic acid and low toxicity. </div>
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Synthesis and antiviral activity of maleopimaric and quinopimaric acids' derivatives.

Synthesis and antiviral activity of maleopimaric and quinopimaric acids' derivatives.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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